23+ Mitochondrial-Derived Vesicles Compensate For Loss Of Lc3-Mediated Mitophagy
These rare autophagy-deficient clones circumvent the lack of canonical autophagy by increasing mitochondrial dynamics and by recycling damaged mitochondria via. Mitochondrial-derived vesicles compensate for loss of LC3-mediated mitophagy---11.
Mitochondrial Fission Integrity And Completion Of Mitophagy Require Separable Functions Of Vps13d In Drosophila Neurons Biorxiv
To identify alternate forms of mitochondrial quality control that functionally compensate if mitophagy is inactive we selected for autophagy-dependent cancer cells that.
. Mitochondrial-derived vesicles compensate for loss of LC3-mediated mitophagy June 2021 Developmental Cell Christina Towers Darya Wodetzki Jacqueline. Mitochondrial-derived vesicles compensate for loss of LC3-mediated mitophagy Graphical abstract Highlights dAutophagy-dependent cells maintain functional mitochondria when. Mitochondrial-derived vesicles compensate for loss of LC3-mediated mitophagy.
1 Alternate mitochondrial pathways compensate for loss of LC3-mediated mitophagy Christina G Towers1 Darya K Wodetzki1 Jackie Thorburn1 Katharine R Smith1 M. Towers Darya Wodetzki 3 authors A. Proteomics characterization of mitochondrial-derived vesicles under oxidative stress.
Mitochondrial-derived vesicles compensate for loss of LC3-mediated mitophagy Dev. Abstract Mitochondria are critical metabolic and signaling hubs and dysregulated mitochondrial homeostasis is implicated in many diseases. The selective degradation of mitochondria via double membrane autophagosome vesicles is called mitophagy.
MDVs precede mitochondrial autophagy and serve as the first line of defense against oxidative stress by selectively transferring damaged mitochondrial substances to the. 2029 - 2042 View Record in Scopus Google Scholar. Cell 56 2021 pp.
We show that the autophagy-dependent cells acquire unique dependencies on these processes indicating that these alternate forms of mitochondrial homeostasis. In addition to structural remodeling of mitochondrial networks mitochondrial fission and fusion are implicated in homeostatic maintenance of mitochondrial dna stability. Damaged mitochondria can generate harmful amounts of.
Thorburn Published 24 June.
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